CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications


An introduction to the CARELL GROUP


carell group laboratories

CARELL GROUP

Laboratories

The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.

News


Inauguration
Inauguration of the Institute for Chemical Epigenetics (ICEM)
Johann de Graaff, 31.05.2022
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The official inauguration ceremony of the Institute for Chemical Epigenetics (ICEM) was held on Monday, 30th of May 2022! Our new research facility focuses on the interplay of chemistry and biology on the level of the genetic code and early life on earth.

Carell in Nature
Unified: A Prebiotic World of RNA and Peptides
Markus Müller, 12.05.2022
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Now online in Nature: Could amino-acid modified RNA bases have served as early building blocks for pre-ribosomal peptide synthesis? Check also the podcast (at 10:54 min).

manQ
Elucidation of the mannosyl-queuosine structure
Johann de Graaff, 08.12.2021
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We have elucidated the structure of the hypermodified tRNA base mannosyl-queuesine. It was synthesized in 33 steps and our data show that
manQ features an α‐allyl connectivity of its sugar moiety.
Check out our publication in Nature Communications!

TET3 in Nature Communications
Gdh fuels TET3 with αKG in neurons
Johann de Graaff, 02.07.2021
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TET enzymes are highly important for the regulation of epigenetic information. We could now show that neuronal glutamate dehydrogenase is located in the nucleus in significant amounts, generating alpha-ketoglutarate, an essential co-substrate for TET3.

Focus of the group


research

CARELL GROUP

A Synonym for Successful DNA Research

RESEARCH

Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

research

EPIGENETIC TOOLS

Novel Phosphoramidites of New Epigenetic Bases

EPIGENETIC TOOLS

The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.

publication

Publications CARELL GROUP

The Complete List

PUBLICATIONS

Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.

research

Lectures and Courses

by the CARELL GROUP

TEACHING

Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories


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