CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications


An introduction to the CARELL GROUP


carell group laboratories

CARELL GROUP

Laboratories

The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.

News


Wiederholungskalusur OC3
Klausur für Organische Chemie 3
Johann de Graaff, 23.01.2023
Bild ist nicht verfügbar

Die Klausur für Organische Chemie 3 wird am Mittwoch, den 15.02.2023 von 08:00 Uhr bis 10:00 Uhr im Buchner-Hörsaal (Haus, Butenandtstr. 5-13, 81377 München) stattfinden. Bitte melden Sie sich hierfür an.

Sting Agonism EMBO
Why T-cells do STING
Johann de Graaff, 27.01.2023
Bild ist nicht verfügbar

We could show that in primary human T cells, the activation of the innate sensor STING leads to antiviral cytokine release. However, T cell functionality is reduced upon STING activation through increased apoptosis, impaired proliferation, and compromised metabolism. Check it out!

Enhanced Click-Chemistry-Based Bioimaging
Click for Bioimaging
Johann de Graaff, 01.11.2022
Bild ist nicht verfügbar

We developed ready-to-click rhodamine dyes with outstanding brightness. They outperform 5-TAMRA-azide and show potential as FRET quenchers. Check it out!

Isoxazole-based Nucleosides Proto-RNA
Proto-Nucleosides from Isoxazole
Johann de Graaff, 05.09.2022
Bild ist nicht verfügbar

Isoxazole-based Nucleosides not only pair with regular RNA, but also convert to pyrimidines. It demonstrates that RNA could evolutionarily emerge from primitive precursor isoxazole ribosides. Check it out!

dd-cAAMP
Stable cGAMP Resists Poxins
Johann de Graaff, 25.07.2022
Bild ist nicht verfügbar

Dideoxy-2′,3′-cGAMP and analogs thereof are poxin-stable STING agonists. Particularly the compound dideoxy-2′,3′-cAAMP features high antitumor response in mice. Check it out!

Focus of the group


research

CARELL GROUP

A Synonym for Successful DNA Research

RESEARCH

Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

research

EPIGENETIC TOOLS

Novel Phosphoramidites of New Epigenetic Bases

EPIGENETIC TOOLS

The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.

publication

Publications CARELL GROUP

The Complete List

PUBLICATIONS

Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.

research

Lectures and Courses

by the CARELL GROUP

TEACHING

Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories


Zum Anfang