CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications


An introduction to the CARELL GROUP


carell group laboratories

CARELL GROUP

Laboratories

The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.

News


Sign up for Coenzymes Exam
Thomas Carell, 29.06.2021
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The exam of Coenzymes & Biosyntheses will take place on 29. July, 10 - 12 in the Buchner-HS. Please register below.

Gdh fuels TET3 with aKG in neurons
Johann de Graaff, 02.07.2021
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TET enzymes are highly important for the regulation of epigenetic
information. We could now show that neuronal glutamate dehydro-
genase is located in the nucleus in significant amounts, generating
alpha-ketoglutarate, an essential co-substrate for TET3.

Widespread Deformylation Events
Markus Müller, 24.06.2021
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To remove methyl-groups in a life-supporting environment is difficult. We could now show that deformylation of cytidine is a process occurring in many different cell types.

Carell Chemistry on ARTE
Thomas Carell, 16.02.2021
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The Carell group with their break through results in prebiotic chemistry on TV!
Click the image above for the full-length video from the Arte Mediathek (German).

Interview with Britta Hundesrügge (FDP)
Thomas Carell, 08.02.2021
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Thomas Carell was interviewed by parliamentary candidate Britta Hundesrügge (FDP) concerming the latest developments in Corona research.

OC3 - Zuckerkapitel jetzt komplett
Thomas Carell, 17.02.2021
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Die finalen Kapiel zum Kohlenhydrate-Teil sind nun verfügbar. Damit ist die Vorlesung zur Bioorganischen Chemie nun komplett.

Fly-over High-Tech Campus
Markus Müller, 26.10.2020
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Watch a fascinating drone flight over our High-Tech Campus Grosshadern / Martinsried.

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Focus of the group


research

CARELL GROUP

A Synonym for Successful DNA Research

RESEARCH

Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.

research

EPIGENETIC TOOLS

Novel Phosphoramidites of New Epigenetic Bases

EPIGENETIC TOOLS

The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.

publication

Publications CARELL GROUP

The Complete List

PUBLICATIONS

Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.

research

Lectures and Courses

by the CARELL GROUP

TEACHING

Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories


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