CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications

An introduction to the CARELL GROUP

carell group laboratories



The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.


OC3 - Zuckersynthese jetzt online
Thomas Carell, 21.01.2021
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Zwei weitere, knapp 30-minütige Videos, vertiefen nun präbiotische Ansätze der Kohlenhydratsynthese.

Fly-over High-Tech Campus
Markus Müller, 26.10.2020
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Watch a fascinating drone flight over our High-Tech Campus Grosshadern / Martinsried.

Demethylation by Repair
Markus Müller, 11.09.2020
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Don't miss our new paper in Nature Chemical Biology about active removal of 5-methylcytosine from the genome of pluripotent cells.

Total Synthesis of galQ
Markus Müller, 06.04.2020
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Check out our new paper in Angewandte Chemie about the total synthesis and quantification of galactosyl queuosine.

Mechanism for RNA-sensing revealed
Markus Müller, 27.11.2019
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Published in Cell: In collaboration with the Hornung group, we characterized th role of RNaseT2 in TLR8 activation.

Our Science went Science!
Martin Rossa, 04.10.2019
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A unified pathway towards purine and pyrimidine formation.
Take a look!


Focus of the group



A Synonym for Successful DNA Research


Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.



Novel Phosphoramidites of New Epigenetic Bases


The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.


Publications CARELL GROUP

The Complete List


Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.


Lectures and Courses



Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

Our laboratories

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