CARELL GROUP – Publications


Publications in chronological order

2021 – Ludwig-Maximilians-Universität München (Germany)


M. Hillmeier, M. Wagner, T. Ensfelder, E. Korytiakova, P. Thumbs, M. Müller, T. Carell

Nat. Commun. 2021, 10.1038/s41467-021-27371-9

“Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine.”


P. Kabaciński, M. Romanelli, E. Ponkkonen, V. K. Jaiswal, T. Carell, M. Garavelli, G. Cerullo, I. Conti

J. Phys. Chem. Lett. 2021, 10.1021/acs.jpclett.1c02909

“Unified Description of Ultrafast Excited State Decay Processes in Epigenetic Deoxycytidine Derivatives.” 


D. Schmidl, N. S. W. Jonasson, E. Korytiaková, T. Carell, L. J. Daumann

Angew. Chem. Int. Ed. 2021, 10.1002/anie.202107277

“Biomimetic Iron Complex Achieves TET Enzyme Reactivity.” 


N. Müller, E. Ponkkonen, T. Carell, A. Khobta

Int. J. Mol. Sci. 2021, 10.3390/ijms222011025

“Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine.” 


E. Kamińska, E. Korytiaková, A. Reichl, M. Müller, T. Carell

Angew. Chem. Int. Ed. 2021, 10.1002/anie.202109995

“Intragenomic decarboxylation of 5-carboxy-2'-deoxycytidine.” 


B. B. Jütte, C. Krollmann, K. Cieslak, R.-M. Koerber, P. Boor, C. M. Graef, E. Bartok, M. Wagner, T. Carell, J. Landsberg, P. Aymans, J. Wenzel, P. Brossart, L. L. Teichmann

iScience 2021, 10.1016/j.isci.2021.102833

“Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.” 


U. Swain, G. Friedlander, U. Sehrawat, A. Sarusi-Portuguez, R. Rotkopf, C. Ebert, T. Paz-Elizur, R. Dikstein, T. Carell, N. E. Geacintov, Z. Livneh

Int. J. Mol. Sci. 2021, 10.3390/ijms22136957

“TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.”


F. R. Traube, D. Özdemir, H. Sahin, C. Scheel, A. F. Glück, A. S. Geserich, S. Oganesian, S. Kostidis, K. Iwan, R. Rahimoff, G. Giorgio, M. Müller, F. Spada, M. Biel, J. Cox, M. Giera, S. Michalakis, T. Carell

Nat. Commun. 2021, 10.1038/s41467-021-24353-9

“Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.” 


L. S. Runtsch, M. Stadlmeier, A. Schön, M. Müller, T. Carell

Chem. Eur. J. 2021, 10.1002/chem.202102159

“Comparative nucleosomal reactivity of 5-formyl-uridine and 5-formyl-cytidine.”


E. Korytiaková, E. Kaminska, M. Müller, T. Carell

Angew. Chem. Int. Ed. 2021, 10.1002/anie.202107089

“Deformylation of 5-formylcytidine in different cell types.”


F. R. Traube, S. Schiffers, T. Carell

Methods Mol. Biol. 2021, 10.1007/978-1-0716-1294-1_6

“Quantification of DNA Methylation and Its Oxidized Derivatives Using LC-MS.”


M. Koch, C. Scheel, H. W. Ma, F. Yang, M. Stadlmeier, A. F. Glück, E. Murenu, F. R. Traube, T. Carell, M. Biel, X.-Q. Ding, S. Michalakis

Int. J. Mol. Sci. 2020, 10.3390/ijms22010052

“The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia.”


K. Fugger, I. Bajrami, M. Silva Dos Santos, S. J. Young, S. Kunzelmann, G. Kelly, G. Hewitt, H. Patel, R. Goldstone, T. Carell, S. J. Boulton, J. MacRae, I. A. Taylor, S. C. West

Science 2021, 10.1126/science.abb4542

“Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.”


F. Schelter, A. Kirchner, F. R. Traube, M. Müller, W. Steglich, T. Carell

Chemistry 2021, 10.1002/chem.202100551

“5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks.”

2020 – Ludwig-Maximilians-Universität München (Germany)


C. B. Mulholland, A. Nishiyama, J. Ryan, R. Nakamura, M. Yiğit, I. M. Glück, C. Trummer, W. Qin, M. D. Bartoschek, F. R. Traube, E. Parsa, E. Ugur, M. Modic, A. Acharya, P. Stolz, C. Ziegenhain, M. Wierer, W. Enard, T. Carell, D. C. Lamb, H. Takeda, M. Nakanashi, S. Bultmann, H. Leonhardt

Nat. Commun. 2020, 10.1038/s41467-020-19603-1

“Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals.”



J. B. Alberge, F. Magrangeas, M. Wagner, S. Denié, C. Guérin-Charbonnel, L. Campion, M. Attal, H. Avet-Loiseau, T. Carell, P. Moreau, S. Minvielle, A. A. Sérandour.

Clin. Epigenetics 2020, 10.1186/s13148-020-00953-y

“DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma” 




F. Spada, S. Schiffers, A. Kirchner, Y.-Q. Zhang, G. Arista, O. Kosmatchev, E. Korytiakova, R. Rahimoff, C. Ebert, T. Carell

Nat. Chem. Biol. 2020, 10.1038/s41589-020-0621-y

“Active turnover of genomic methylcytosine in pluripotent cells” 




T. Lauria, C. Slator, V. McKee, M. Müller, S. Stazzoni, A. L. Crisp, T. Carell, A. Kellett

Chemistry. 2020, 10.1002/chem.202002860

“A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors” 




C. B. Mulholland, F. R. Traube, E. Ugur, E. Parsa , E. M. Eckl, M. Schönung, M. Modic, M. D. Bartoschek, P. Stolz, J. Ryan, T. Carell, H. Leonhardt, S. Bultmann

Sci. Rep. 2020, 10.1038/s41598-020-68600-3

“Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency."





R. C. A. Dubini, A. Schön , M. Müller, T. Carell, P. Rovó

Nucleic Acids Res. 2020, 10.1093/nar/gkaa589

“Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange” 




M. Nainytè, F. Müller, G. Ganazzoli, C.-Y. Chan, A. Crisp, D. Globisch, T. Carell

Chem. Eur. J. 2020, 10.1002/chem202002929

“Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World”




N. Raddaoui, S. Croce, F. Geiger, A. Borodavka, L. Möckl, S. Stazzoni, B. Viverge, C. Bräuchle, T. Frischmuth, H. Engelke, T. Carell

ChemBioChem 2020, doi: 10.1002/cbic.202000081

“Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry”




E. C. Beckwitt, S. Jang, I. C. Detweiler, J. Kuper, F. Sauer, N. Simon, J. Bretzler, S. C. Watkins, T. Carell, C. Kisker, B. Van Houten

Nat. Comm. 2020, doi: 10.1038/s41467-020-15168-1

“Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search”




P. Thumbs, T. T. Ensfelder, M. Hillmeier, M. Wagner, M. Heiss, C. Scheel, A. Schön, M. Müller, S. Michalakis, S. Kellner, T. Carell

Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202002295

“Synthesis of galactosyl‐queuosine and distribution of hypermodified Q‐nucleosides in mouse tissues”




M. Nainyté, T. Carell

Helv. Chim. Acta 2020, doi: 10.1002/hlca.202000016

"Synthesis and incorporation of k2U into RNA"




A. Schön, E. Kaminska, F. Schelter, E. Ponkkonen, E. Korytiaková, S. Schiffers, T. Carell

Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202000414

"Analysis of an active deformylation mechanism of 5-formyl-deoxycytidine (fdC) in stem cells"




S. Croce, S. Serdjukow, T. Carell, T. Frischmuth

ChemBioChem 2020, doi: 10.1002/cbic.201900718

"Chemo‐Enzymatic Preparation of Functional Click Labelled Messenger RNA"


2019 – Ludwig-Maximilians-Universität München (Germany)




W. Greulich, M. Wagner, M.M. Gaidt, C. Stafford, Y. Cheng, A. Linder, T. Carell, V. Hornung

Cell 2019, doi: 10.1016/j.cell.2019.11.001

"TLR8 Is a Sensor of RNase T2 Degradation Products"


In the press


A. Crisp

Nature - Behind the Paper 2019

"Purines and Pyrimidines: Structure out of Soup"




M. Stadlmeier, L. S. Runtsch, F. Streshnev, M. Wühr, T. Carell

ChemBioChem. 2019, doi: 10.1002/cbic.201900611

"A Click‐chemistry based enrichable cross‐linker for structural and protein interaction analysis by mass spectrometry"




S. Becker, J. Feldmann, S. Wiedemann, H. Okamura, C. Schneider, K. Iwan, A. Crisp, M. Rossa, T. Amatov, T. Carell

Science 2019, doi: 10.1126/science.aax2747

"Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides"




H. Okamura, A. Crisp, S. Hübner, S. Becker, P. Rovo, T. Carell

Angew. Chem. Int. Ed. 2019, doi: 10.1002/anie.201911746

"proto‐Urea‐RNA (Wöhler RNA) containing unusually stable urea nucleosides"




S. A. Benner, E. A. Bell, E. Biondi, R. Brasser, T. Carell, H.-J. Kim, S. J. Mojzsis, A. Omran, M. A. Pasek, D. Trail

ChemSystemsChem 2019, doi: 10.1002/syst.201900035

"When Did Life Likely Emerge on Earth in an RNA‐First Process?"




J. Gontcharov, B. Pilles, L. Liu, T. Carell, W. Schreier, W. Zinth

Chem. E. J. 2019, doi: 10.1002/chem.201903573

"Triplet Induced Lesion Formation at CpT and TpC sites in DNA"



M. Nainytė, T. Amatov, T. Carell

Chem. Commun. 2019, doi:10.1039/c9cc06314e

"Synthesis of an acp3U phosphoramidite and incorporation of the hypermodified base into RNA"



N. Kitsera, M. Rodriguez-Alvarez, S. Emmert, T. Carell, A. Khobta

Nucleic Acids Res. 2019, doi: 10.1093/nar/gkz558

"Nucleotide excision repair of abasic DNA lesions"



T. M. Wildenhof, S. Schiffers, F. R. Traube, P. Mayer, T. Carell

Angew. Chem. Int. Ed. 2019, doi: 10.1002/anie.201904794

"Influencing epigenetic information with a hydrolytically stable carbocyclic 5-aza-2'-deoxycytidine"



S. Schiffers, T. M. Wildenhof, K. Iwan, M. Stadlmeier, M. Müller and T. Carell

Helv. Chim. Acta. 2019, doi: 10.1002/hlca.201800229

"Label‐Free Quantification of 5‐Azacytidines Directly in the Genome"



H. Okamura, S. Becker, N. Tiede, S. Wiedemann, J. Feldmann and T. Carell

Chem. Commun. 2019, doi: 10.1039/C8CC09435G

"A one‐pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions"


>>highlighted in Synfacts 2019; 15(05): 0476, DOI: 10.1055/s-0037-1612513


2018 – Ludwig-Maximilians-Universität München (Germany)


F.R. Traube, S. Schiffers, K. Iwan, S. Kellner, F. Spada, M. Müller, T. Carell

Nat. Protoc. 2018, doi: 10.1038/s41596-018-0094-6

"Isotope-dilution mass spectrometry for exact quantication of noncanonical DNA nucleosides"


S. Becker, C. Schneider, A. Crisp, T. Carell

Nat. Commun. 2018, doi: 10.1038/s41467-018-07222-w

"Non-canonical nucleosides and chemistry of the emergence of life"


C. R. Dialer, S. Stazzoni, D. J. Drexler, F. M. Müller, S. Veth, A. Pichler, H. Okamura, G. Witte, K.-P. Hopfner and T. Carell

Chem. Eur. J. 2018, doi: 10.1002/chem.201805409

"A Click-Chemistry Linked 2'3'-cGAMP Analog"


>> highlighted in Synfacts 2019; 15(04): 0434; DOI: 10.1055/s-0037-1612408

In the press

Robert F. Service

Science News 2018, doi: 10.1126/science.aav7778

"Chemists find a recipe that may have jump-started life on Earth"


A. Rajavelu, C. Lungu, M. Emperle, M. Dukatz, A. Brohm, J. Broche, I. Hanelt, E. Parsa, S. Schiffers, R. Karnik, A. Meissner, T. Carell, P. Rathert, R. Z. Jurkowska, A. Jeltsch

Nucleic Acids Res. 2018, doi: 10.1093/nar/gky715

"Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2"


T. T. Ensfelder, M. Q. Kurz, K. Iwan, S. Geiger, S. Matheisl, M. Müller, R. Beckmann, T. Carell

Chem. Commun. 2018, doi: 10.1039/C8CC03980A

"ALKBH5-Induced Demethylation of Mono- and Dimethylated Adenosine"


A. Crisp, T. Carell

eLife 2018, doi: 10.7554/eLife.38297

"In Vitro Evolution: Rethinking the tools of the RNA world"


C. Schneider, S. Becker, H. Okamura, A. Crisp, T. Amatov, M. Stadlmeier, T. Carell

Angew. Chem. Int. Ed. 2018, doi:10.1002/anie.201801919

"Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations"


S. Becker, C. Schneider, H. Okamura, A. Crisp, T. Amatov, M. Dejmek, T. Carell

Nat. Commun. 2018, doi:10.1038/s41467-017-02639-1

"Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis"


M. Stadlmeier, J. Bogena, M. Wallner, T. Carell

Angew. Chem. Int. Ed. 2018, doi:10.1002/anie.201708867

"A sulfoxide-based isobaric labelling reagent for accurate quantitative mass spectrometry"

2017 – Ludwig-Maximilians-Universität München (Germany)


K. Iwan, R. Rahimoff, A. Kirchner, F. Spada, A.S. Schröder, O. Kosmatchev, S. Ferizaj, J. Steinbacher, E. Parsa, M. Müller, T. Carell

Nat. Chem. Biol. 2017, doi:10.1038/nchembio.2531

"5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo"


I.N. Michaelides, N. Tago, B. Viverge, T. Carell

Chem. Eur. J. 2017, doi: 10.1002/chem.201704216

"Synthesis of RNA Containing 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine"


T. Carell, M.Q. Kurz, M. Müller, M. Rossa, F. Spada

Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201708228

"Non-canonical bases in the genome: The regulatory information layer in DNA"



R.R. Edupuganti, S. Geiger, R.G.H. Lindeboom, H. Shi, P.J. Hsu, Z. Lu, S.-Y. Wang, M.P.A. Baltissen, P.W.T.C. Jansen, M. Rossa, M. Müller, H.G. Stunnenberg, C. He*, T. Carell*, M. Vermeulen*

Nat. Struct. Mol. Biol. 2017, doi:10.1038/nsmb.3462

"N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis"


N. Kitsera, J. Allgayer, E. Parsa, N. Geier, M. Rossa, T. Carell, A. Khobta

Nucleic Acids Res. 2017, doi: 10.1093/nar/gkx718

"Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter."


R. Rahimoff, O. Kosmatchev, A. Kirchner, T. Pfaffeneder, F. Spada, V. Brantl, M. Müller, T. Carell

J. Am. Chem. Soc. 2017, doi: 10.1021/jacs.7b04131

"5-Formyl- and 5-carboxydeoxycytidines do not cause accumulation of harmful repair intermediates in stem cells."


N. Raddaoui, S. Stazzoni, L. Möckl, B. Viverge, F. Geiger, H. Engelke, C. Bräuchle, T. Carell

ChemBioChem 2017, doi: 10.1002/cbic.201700209

"Dendrimer-based signal amplification of click-labelled DNA in situ."


F. R. Traube, T. Carell

RNA Biol. 2017, 25, 1-9 doi: 10.1080/15476286

"The chemistries and consequences of DNA and RNA methylation and demethylation."


C. Ebert, N. Simon, S. Schneider, T. Carell

ChemBioChem 2017, doi: 10.1002/cbic.201700169

"Structural insights into the recognition of N2-aryl- and C8-aryl DNA lesions by the repair protein XPA/Rad14."


S. Schiffers, C. Ebert, R. Rahimoff, O. Kosmatchev, J. Steinbacher, A.-V. Bohne, F. Spada, S. Michalakis, M. Müller, T. Carell

Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201700424

"Quantitative LC-MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues."

2016 – Ludwig-Maximilians-Universität München (Germany)


A. S. Schröder, E. Parsa, K. Iwan, F. R. Traube, M. Wallner, S. Serdjukow, T. Carell

Chem. Commun. 2016, doi:10.1039/C6CC07517G

"2´-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes."


L. Heidinger, A. Kneuttinger, G. Kazshiwazaki, S. Weber, T. Carell, E. Schleicher

FEBS Lett. 2016, doi:10.1002/1873-3468.12498

"Direct Observation of a Deoxyadenosyl Radical in an Active Enzyme Environment."


A. Dallmann, A. Beribisky, F. Gnerlich, M. Rübbelke, S. Schiesser, T. Carell, M. Sattler

Chem. Eur. J. 2016, 22(43), 15350-15359 doi:10.1002/chem.201602784

"Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex."


M. Su, A. Kirchner, S. Stazzoni, M. Müller, M. Wagner, A. S. Schröder, T. Carell

Angew. Chem. Int. Ed. 2016, 55(39), 11797-11800 doi:10.1002/anie.201605994

"5-Formylcytosine could be a Semipermanent Base in Specific Genome Sites."


A. S. Schröder, O. Kotljarova, E. Parsa, K. Iwan, N. Raddaoui, T. Carell

Org. Lett. 2016, 18(17), 4368-4371 doi:10.1021/acs.orglett.6b02110

"Synthesis of (R)-Configured 2´-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides."


B. Thienpont, J. Steinbacher, H. Zhao, F. D'Anna, A. Kuchnio, A. Ploumakis, B. Ghesquière, L. Van Dyck, B. Boeckx, L. Schoonjans, E. Hermans, F. Amant, V. N. Kristensen, K. P. Koh, M. Mazzone, M. L. Coleman, T. Carell, P. Carmeliet, D. Lambrechts

Nature, 2016, 537, 63-68 doi:10.1038/nature19081

"Tumour hypoxia causes DNA hypermethylation by reducing TET activity."


C. M. Greco, P. Kunderfranco, M. Rubino, V. Larcher, P. Carullo, A. Anselmo, K. Kurz, T. Carell, A. Angius, M. V. G. Latronico, R. Papait, G. Condorelli

Nature Comm. 2016, 7, 12418 doi:10.1038/ncomms12418

"DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy."


N. Simon, C. Ebert, S. Schneider

Chem. Eur. J. 2016, 22(31), 10782-10785 doi:10.1002/chem.201602438

"Structural Basis for Bulky-Adduct DNA-Lesion Recognition by the Nucleotide Excision Repair Protein Rad14."


S. Becker, I. Thoma, A. Deutsch, T. Gehrke, P. Mayer, H. Zipse, T. Carell

Science, 2016, 352(6287), 833-836 doi:10.1126/science.aad2808

"A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway."


S. C. Koch, N. Simon, C. Ebert, T. Carell

Quaterly Reviews of Biophysics, 2016, 49, e5 doi:10.1017/S0033583515000268

"Molecular mechanisms of xeroderma pigmentosum (XP) proteins."


O. Bogdanovic, A. H. Smits, E. de la Calle Mustienes, J. J. Tena, E. Ford, R. Williams, U. Senanayake, M. D. Schultz, S. Hontelez, I. van Kruijsbergen, T. Rayon, F. Gnerlich, T. Carell, G. J. C. Veenstra, M. Manzanares, T. Sauka-Spengler, J. R. Ecker, M. Vermeulen, J. L. Gómez-Skarmeta, R. Lister

Nature Genetics, 2016, 48, 417-426 doi:10.1038/ng.3522

"Active DNA demethylation at enhancers during the vertebrate phylotypic period."


L. Klier, E. Aranzamendi, D. Ziegler, J. Nickel, K. Karaghiosoff, T. Carell, P. Knochel

Org. Lett. 2016, 18(5), 1068-1071 doi:10.1021/acs.orglett.6b00190

"Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines."


S. Datz, C. Argyo, M. J. Gattner, V. Weiss, K. Brunner, J. Bretzler, C. von Schirnding, A. A. Torrano, F. Spada, M. Varbel, H. Engelke, C. Bräuchle, T. Carell, T. Bein

Nanoscale, 2016, 8, 8101-8110 doi:10.1039/C5NR08163G

"Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release."


D. B. Bucher, C. L. Kufner, A. S. Schulter, T. Carell, W. Zinth

J. Am. Chem. Soc. 2016, 138(1), 186-190 doi:10.1021/jacs.5b09753

"UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair."

2015 – Ludwig-Maximilians-Universität München (Germany)


N. C. Gassen, G. R. Fries , A. S. Zannas , J. Hartmann , J. Zschocke , K. Hafner , T. Carrillo-Roa , J. Steinbacher , S. N. Preißinger , L. Hoeijmakers , M. Knop , F. Weber , S. Kloiber , S. Lucae , G.P. Chrousos , T. Carell , M. Ising , E. B. Binder , M. V. Schmidt , J. Rüegg , T. Rein

Science Signal. 2015, 8(404), ra119, doi:10.1126/scisignal.aac7695

"Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine."


D. B. Bucher, B. M. Pilles, T. Carell, W. Zinth

J. Phys. Chem. B, 2015, 119(28), 8685-8692

"Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases."


M. Wagner, J. Steinbacher, T. F. Kraus, S. Michalakis, B. Hackner, T. Pfaffeneder, A. Perera, M. Müller, A. Giese, H. A. Kretzschmar, T. Carell

Angew. Chem. Int. Ed. 2015, 54(42), 12511-12514 doi:10.1002/anie.2015027225

"Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues."


L. Schuster, L. Rothmund, X. He, Kirsten L. V. Landuyt, H. Schweikl, E. Hellwig, T. Carell, R. Hickel, F.-X. Reichl, C. Högg

Dent. Mater. 2015, 31(6), 745-757

"Effect of Opalescence® bleaching gels on the elution of dental composite components."


S. C. Koch, J. Kuper, K. L. Gasteiger, N. Simon, R. Strasser, D. Eisen, S. Geiger, S. Schneider, C. Kisker, T. Carell

PNAS, 2015, doi:10.1073/pnas.1508509112

"Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)"


L. Rothmund, M. Shehata, K. L. Van Landuyt, H. Schweikl, T. Carell, W. Geurtsen, E. Hellwig, R. Hickel, F.-X. Reichl, C. Högg

Dent. Mater. 2015, 31(6), 496-504 doi:10.1016/

"Release and protein binding of components from resin based composites in native saliva and other extraction media"


S. Schiesser, B. Hackner, M. Vrabel, W. Beck, T. Carell

Eur. J. Org. Chem. 2015, 2654-2660

"Synthesis and DNA-Damaging Properties of Cisplatin-N-Mustard Conjugates"


M Ehrlich, M. J. Gattner, B. Viverge, J. Bretzler, D. Eisen, M. Stadlmeier, M. Vrabel, T. Carell

Chem. Eur. J. 2015, 21, 1-5

"Orchestrating the Biosynthesis of an Unnatural Pyrrolysine Amino Acid for Its Direct Incorporation into Proteins Inside Living Cells"


A. Perera, D. Eisen, M. Wagner, S. K. Laube, A. F. Künzel, S. Koch, J. Steinbacher, E. Schulze, V. Splith, N. Mittermeier, M. Müller, M. Biel, T. Carell, S. Michalakis

Cell Rep. 2015, 11, 1-12

"TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression"


L. Penter, B. Maier, U. Frede, B. Hackner, T. Carell, C. Hagemeier, M. Truss

Target Oncol. 2015, doi:10.1007/s11523-014-0354-5

"A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma"


M. Su, M. Tomas–Gamasa, T. Carell

Chem. Sci. 2015, 6, 632-638

"DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides"

2014 – Ludwig-Maximilians-Universität München (Germany)


K. Brunner, J. Harder, T. Halbach, J. Willibald, F. Spada, F. Gnerlich, K. Sparrer, A. Beil, L. Möckl, C. Bräuchle, K-K Conzelmann, T. Carell

Angew. Chem. Int. Ed. 2014, 53, 1-5

"Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures"


M. Tomas–Gamasa, S. Serdjukow, M. Su, M. Müller, T. Carell

Angew. Chem. Int. Ed. 2014, 54, 796-800

"Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link


O. Ziv, A. Zeisel, N. Mirlas-Neisberg, U. Swain, R. Nevo, N. Ben-Chetrit, M. Paola Martelli, R. Rossi, S.n Schiesser, C. E. Canman, T. Carell, N. E. Geacintov, B. Falini, E. Domany, Z. Livneh

Nature Comm. 2014, 5:5437

"Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin."


A. Benjdia, K. Heil, A. Winkler, T. Carell, I. Schlichting.

Chem. Commun. 2014, 50, 14201-14204

"Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase"


D. B. Bucher, A. Schlueter, T. Carell, W. Zinth

Angew. Chem. Int. Ed. 2014, 53, 11366-11369

"Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA"


A. Biela, F. Coste, F. Culard, M. Guerin, S. Goffinont, K. Gasteiger, J. Cieśla, A. Winczura, Z. Kazimierczuk, D. Gasparutto, T. Carell, B. Tudek, B. Castaing

Nucleic Acids Res. 2014, 42, 10748-10761

"Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization"


K. Sadeghian, D. Flaig, I. D. Blank, S. Schneider, R. Strasser, D. Stathis, M. Winnacker, T. Carell, C. Ochsenfeld

Angew. Chem. Int. Ed. 2014, 53, 10044-10048

"Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study"


L. I. Kroeze, M. G. Aslanyan, A. van Rooij, T. N. Koorenhof-Scheele, M. Massop, T. Carell, J. B. Boezeman, J.-P. Marie, C. J. M. Halkes, T. de Witte, G. Huls, S. Suciu, R. A. Wevers, B. A. van der Reijden, J. H. Jansen

Blood 2014, 124, 1110-1118

"Characterization of acute myeloid leukemia based on levels of global hydroxymethylation"


T. Pfaffeneder, F. Spada, M. Wagner, C. Brandmayr, S. K. Laube, D. Eisen, M. Truss, J. Steinbacher, B. Hackner, O. Kotljarova, D. Schuermann, S. Michalakis, O. Kosmatchev, S. Schiesser, B. Steigenberger, N. Raddaoui, G. Kashiwazaki, U. Müller, C. G. Spruijt, M. Vermeulen, H. Leonhardt, P. Schär, M. Müller & T. Carell

Nature Chem. Biol. 2014, 10, 574-581

"Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA"


N. Kitsera, K. Gasteiger, B. Lühnsdorf, J. Allgayer, B. Epe, T. Carell, A. Khobta

PLOS One 2014, 9(4), e94405

"Cockayne Syndrome: Varied Requirement of Transcription-Coupled Nucleotide Excision Repair for the Removal of Three Structurally Different Adducts from Transcribed DNA"


S. Serdjukow, F. Kink, B. Steigenberger, M. Tomas–Gamasa, T. Carell

Chem. Commun. 2014, 50, 1861-1863

"Synthesis of γ-labeled nucleoside 5'-triphosphates using click chemistry"


D.B. Bucher, B.M. Pilles, T. Carell, W. Zinth

Proc. Natl. Acad. Sci. USA, 2014, 111(12), 4369-4374

"Charge separation and charge delocalization identified in long-living states of photoexcited DNA"


P. Bashtrykov, A. Rajavelu, B. Hackner, S. Ragozin, T. Carell, A. Jeltsch

ChemBioChem, 2014, 15, 743-8

"Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain"


D.B. Bucher, B.M. Pilles, T. Pfaffeneder, T. Carell, W. Zinth

Chemphyschem, 2014, 15, 420-3

"Fingerprinting DNA oxidation processes: IR characterization of the 5-methyl-2´-deoxycytidine radical cation"


C.N. Buechner, K. Heil, G. Michels, T. Carell, C. Kisker, I. Tessmer

J. Biol. Chem. 2014, 289, 3613-3624

"Strand specific recognition of DNA damages by XPD provides insights into Nucleotide Excision Repair substrate versatility"


M. Su, M. Tomás-Gamasa, S. Serdjukow, P. Mayer, T. Carell

Chem. Commun. (Camb.) 2014, 50, 409-411

"Synthesis and properties of a Cu(II) complexing pyrazole ligandoside in DNA"


A.S. Schröder, J. Steinbacher, B. Steigenberger, F.A. Gnerlich, S. Schiesser, T. Pfaffeneder, T. Carell

Angew. Chem. Int. Ed. 2014, 53, 315-8 (selected as Hot-Paper)

"Synthesis of a DNA Promoter Segment Containing All Four Epigenetic Nucleosides: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxy-2’-Deoxycytidine"


A.C. Kneuttinger, G. Kashiwazaki, S. Prill, K. Heil, M. Müller, T. Carell

Photochem. Photobiol. 2014, 90, 1-14

"Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions"

2013 – Ludwig-Maximilians-Universität München (Germany)


I. Thoma, T. Carell

Eur. J. Org. Chem. 2013, 21, 4483-85

"Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine"


M. Vrabel, P. Kölle, K.M. Brunner, M.J. Gattner, V. López-Carillo, R. de Vivie-Riedle, T. Carell

Chemistry, 2013, 19, 13309-12

"Norbornenes in Inverse Electron-Demand Diels-Alder Reactions"


S. Schneider, M.J. Gattner, M. Vrabel, V. Flügel, V. López-Carillo, S. Prill, T. Carell

ChemBioChem, 2013, 14, 2114-8

"Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins"


S. Schiesser, T. Pfaffeneder, K. Sadeghian, B. Hackner, B. Steigenberger, A.S. Schröder, J. Steinbacher, G. Kashiwazaki, G. Höfner, K.T. Wanner, C. Ochsenfeld, T. Carell

J. Am. Chem. Soc. 2013, 135, 14593-9

"Deamination, Oxidation and C-C bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxycytosine"


M. Shehata, J. Durner, A. Eldenez, K. Van Landuyt, P. Styllou, L. Rothmund, R. Hickel, H. Scherthan, W. Geurtsen, B. Kaina, T. Carell, F.X. Reichl

Dent. Mater. 2013, 29, 971-9

"Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts"


K. Groll, S.M. Manolikakes, X.M. du Jourdin, M. Jaric, A. Bredihhin, K. Karaghiosoff, T. Carell, P. Knochel

Angew. Chem. Int. Ed. 2013, 52, 6776-80

"Regioselective Metalations of Pyrimidines and Pyrazines by Using Frustrated Lewis Pairs of BF3-OEt2 and Hindered Magnesium- and Zinc-Amide Bases"


T.H. Gehrke, U. Lischke, K.L. Gasteiger, S. Schneider, S. Arnold, H.C. Müller, D.S. Stephenson, H. Zipse T. Carell

Nature Chem. Biol. 2013, 9, 455-61

"Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions"


C.G. Spruijt, F. Gnerlich, A.H. Smits, T. Pfaffeneder, P.W.T.C. Jansen, C. Bauer, M. Münzel, M. Wagner, M. Müller, F. Khan, H.C. Eberl, A. Mensinga, A.B. Brinkman, K. Lephikov, U. Müller, J. Walter, R. Boelens, H. van Ingen, H. Leonhardt, T. Carell∗, M. Vermeulen∗

Cell 2013, 152, 1146-59.

"Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives"


A. Hienzsch, C. Deiml, V. Reiter, T. Carell

Chemistry 2013, 19, 4244-8.

"Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials"


B. Steigenberger, S. Schiesser, B. Hackner, C. Brandmayr, S.K. Laube, J. Steinbacher, T. Pfaffeneder, T. Carell

Org. Lett. 2013, 15, 366-369.

"Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction"


M. Ehrlich, T. Carell

Eur. J. Org. Chem. 2013, 1, 77-83.

"Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling"


A.C. Kneuttinger, K. Heil, G. Kashiwazaki, T. Carell

Chem. Commun. (Camb.) 2013, 49, 722-724

"The Radical SAM Enzyme Spore Photoproduct Lyase Employs a Tyrosyl Radical for DNA Repair"


M.J. Gattner, M. Vrabel, T. Carell

Chem. Commun. (Camb.) 2013, 49, 379-381

"Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system"

2012 – Ludwig-Maximilians-Universität München (Germany)


C. Brandmayr, M. Wagner, T. Brückl, D. Globisch, D. Pearson, A.C. Kneuttinger, V. Reiter, A. Hienzsch, S. Koch, I. Thoma, P. Thumbs, S. Michalakis, M. Müller, M. Biel, T. Carell

Angew. Chem. Int. Ed. 2012, 51, 11162-5.

Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency


T.F. Kraus, D. Globisch, M. Wagner, S. Eigenbrod, D. Widmann, M. Münzel, M. Müller, T. Pfaffeneder, B. Hackner, W. Feiden, U. Schüller, T. Carell, H.A. Kretzschmar

Int. J. Cancer. 2012, 131, 1577-90.

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base" are associated with anaplasia in human brain tumors


J. Willibald, J. Harder, K. Sparrer, K.-K. Conzelmann, T. Carell

J. Am. Chem. Soc. 2012, 134, 12330-3.

Click Modified Anandamide siRNA Enables Delivery and Gene Silencing in Neuronal and Immune Cells


J. Timper, K. Gutsmiedl, C. Wirges, J. Broda, M. Noyong, J. Mayer, T. Carell, U. Simon

Angew. Chem. Int. Ed. 2012, 51, 7586-8.

Surface "Click" Reaction of DNA followed by Directed Metalization for the Construction of Contactable Conducting Nanostructures


T. Carell, C. Brandmayr, A. Hienzsch, M. Müller, D. Pearson, V. Reiter, I. Thoma, P. Thumbs, M. Wagner,

Angew. Chemie. Int. Ed. 2012, 51, 7110-7131.

Structure and Function of Noncanonical Nucleobases


A. Benjdia, K. Heil, T. R. Barends, T. Carell, I. Schlichting

Nucleic Acids Res. 2012, 40, 9308-18

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme


V. Reiter, D. M. S. Matschkal, M. Wagner, D. Globisch, A. C. Kneuttinger, M. Müller, T. Carell

Nucleic Acids Res. 2012, 40, 6235-6240.

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA


S. Schiesser, P. Mayer, T. Carell, W. Beck

Z. Naturforsch. 2012, 67b, 849-852.

Molecular and Crystal Structure of Potassium-l-alaninato-dichloridoplatinate(II), K[Pt(l-alaO)Cl2]


S. Schiesser, B. Hackner, T. Pfaffeneder, M. Müller, C. Hagemeier, M. Truss, T. Carell

Angew. Chemie. Int. Ed. 2012, 51, 6516-6520.

Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing


B.P. Fingerhut, S. Oesterling, K. Haiser, K. Heil, A. Glas, W.J. Schreier, W. Zinth, T. Carell, R. de Vivie-Riedle

J. Chem. Phys. 2012, 136, 204307.

ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled dewar valence isomerization


E. Kaya, M. Vrabel, C. Deiml, S. Prill, V. S. Fluxa, T. Carell.

Angew. Chem. Int. Ed. 2012, 51, 4466-9.

A Genetically encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-free Click Reaction


C. Walmacq, A.C. Cheung, M.L. Kireeva, L. Lubkowska, C. Ye, D. Gotte, J. N. Strathern, T. Carell, P. Cramer, M. Kashlev

Mol. Cell. 2012, 46, 18-29.

Mechanism of Translesion Transcription by RNA Polymerase II and its Role in Cellular Resistance to DNA Damage


D. Stathis, U. Lischke, S. C. Koch, C. A. Deiml, T. Carell

J. Am. Chem. Soc. 2012, 134, 4925-30.

Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway


K. Haiser, B. P. Fingerhut, K. Heil, A. Glas, T. T. Herzog, B. M. Pilles, W. J. Schreier, W. Zinth, R. de Vivie-Riedle, T. Carell

Angew. Chem. Int. Ed. 2012, 51, 408-11.

Mechanism of UV-Induced Formation of Dewar Lesions in DNA


N. Diamant, A. Hendel, I. Vered, T. Carell, T. Reissner, N. de Wind, N. Geacinov, Z. Livneh

Nucleic Acids Res. 2012, 40, 170-80.

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

2011 – Ludwig-Maximilians-Universität München (Germany)


M. Münzel, U. Lischke, D. Stathis, T. Pfaffeneder, F. A. Gnerlich, C. A. Deiml, S. C. Koch, K. Karaghiosoff, T. Carell

Chemistry 2011, 17, 13782-13788.

Selected as News Item in "Chemistry Views" on 22 November 2011 Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine


F. Civril, M. Bennett, M. Moldt, T. Deimling, G. Witte, S. Schiesser, T. Carell, K. P. Hopfner

EMBO Rep. 2011, 12, 1127-34.

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling


D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. Kneuttinger, M. Müller, S. Sieber, T. Carell

Angew. Chem. Int. Ed. 2011, 50, 9739-9742.

Systems-Based Analysis of Modified tRNA Bases


J. Fei, N. Kaczmarek, A. Luch, A. Glas, T. Carell, H. Naegeli

PLoS Biol. 2011, 9, e1001183.

Regulation of Nucleotide Excision Repair by UV-DDB: Prioritization of Damage Recognition to Internucleosomal DNA


S. Kiontke, Y. Geisselbrecht, R. Pokorny, T. Carell, A. Batschauer, L. O. Essen

EMBO J. 2011, 30, 4437-49.

Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA


A. Hendel, P. H. Krijger, N. Diamant, Z. Goren, P. Langerak, J. Kim, T. Reissner, K. Y. Lee, N. E. Geacintov, T. Carell K. Myung, S. Tateishi, A. D’Andrea, H. Jacobs, Z. Livneh

PLoS Genet. 2011, 7, e1002262.

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells


C. Kaul, M. Müller, M. Wagner, S. Schneider, T. Carell

Nature Chem. 2011, 3, 794-800.

Reversible bond formation enables replication and amplification of a crosslinking salen complex as an orthogonal base pair


M. Vrabel, E. Kaya, S. Prill, V. Ehmke, T. Carell

Collect. Czech. Chem. Commun. 2011, 76, 1089-1101.

Optimization of the posttranslational click modification of proteins


K. Heil, A. C. Kneuttinger, S. Schneider, U. Lischke, T. Carell

Chemistry 2011, 17, 9651-7.

Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the UV-Induced Spore Photoproduct DNA Lesion


A. Stadler, J. O. Delos Santos, E. S. Stensrud, A. Dembska, G. L. Silva, S. Liu, N. I. Shank, E. Kunttas-Tatli, C. J. Sobers, P. M. E. Gramlich, T. Carell, L. A. Peteanu, B. M. McCartney, B. A. Armitage

Bioconjug. Chem. 2011, 22, 1491-502.

Fluorescent DNA Nanotags Featuring Covalently Attached Intercalating Dyes: Synthesis, Antibody Conjugation, and Intracellular Imaging


K. Heil, D. Pearson, T. Carell

Chem. Soc. Rev. 2011, 40, 4271-8.

Chemical investigation of light induced DNA bipyrimidine damage and repair


Y. V. Le Bihan, M. Angeles Izquierdo, F. Coste, P. Aller, F. Culard, T. H. Gehrke, K. Essalhi, T. Carell, B. Castaing

Nucleic Acids Res. 2011, 39, 6277-90.

5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases


N. Kitsera, D. Stathis, B. Lühnsdorf, H. Müller, T. Carell, B. Epe, A. Khobta

Nucleic Acids Res. 2011, 39, 5926-34.

8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1


T. Pfaffeneder, B. Hackner, M. Truss, M. Münzel, M. Müller, C. A. Deiml, C. Hagemeier, T. Carell

Angew. Chem. Int. Ed. 2011, 50, 7008-12.

The discovery of 5-formylcytosine in embryonic stem cell DNA


M. Münzel, D. Globisch, T. Carell

Angew. Chem. Int. Ed. 2011, 50, 6460-8.

5-Hydroxymethylcytosine, the sixth base of the genome


D. Pearson, T. Carell

Nucleic Acids Res. 2011, 39, 4818-26.

Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U


D. Pearson, A. Hienzsch, M. Wagner, D. Globisch, V. Reiter, D. Özden, T. Carell

Chem. Commun. (Camb.) 2011, 47, 5196-8.

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA


M. Münzel, C. Szeibert, A. F. Glas, D. Globisch, T. Carell

J. Am. Chem. Soc. 2011, 133, 5186-9.

Discovery and synthesis of new UV-induced intrastrand C(4-8)G and G(8-4)C photolesions


M. Wenninger, D. Fazio, U. Megerle, C. Trindler, S. Schiesser, E. Riedle, T. Carell

ChemBioChem 2011, 12, 703-6.

Flavin-induced DNA photooxidation and charge movement probed by ultrafast transient absorption spectroscopy


S. Zimdars, X. Mollat du Jourdin, F. Crestey, T. Carell, P. Knochel

Org. Lett. 2011, 13, 792-795.

Trifunctionalization of the Purine Scaffold Using Mg and Zn Organometallic Intermediates


D. Fazio, C. Trindler, K. Heil, C. Chatgilialoglu, T. Carell

Chemistry 2011, 17, 206-212.

Investigation of Excess-Electron Transfer in DNA Double-Duplex Systems Allows Estimation of Absolute Excess-Electron Transfer and CPD Cleavage Rates

2010 – Ludwig-Maximilians-Universität München (Germany)


D. Globisch, M. Münzel, M. Müller, S. Michalakis, M. Wagner, S. Koch, T. Brückl, M. Biel, T. Carell

PLoS One 2010, 5, e15367.

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates


M. Münzel, D. Globisch, C. Trindler, T. Carell

Org. Lett. 2010, 12, 5671-5673.

Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA


S. Schorr, T. Carell

ChemBioChem 2010, 11, 2534-2537.

Mechanism of Acetylaminofluorene-dG Induced Frameshifting by Polymerase η


S. Schorr, S. Schneider, K. Lammens, K.-P. Hopfner, T. Carell

Proc. Natl. Acad. Sci. USA 2010, 107, 20720-20725.

Mechanism of replication blocking and bypass of Y-family polymerase η by bulky acetylaminofluorene DNA adducts


M. Münzel, L. Lercher, M. Müller, T. Carell

Nucleic Acids Res. 2010, 38, e192.

Chemical discrimination between dC and 5MedC via their hydroxylamine adducts


S. Schneider, T. Reissner, O. Ziv, Z. Livneh, T. Carell

ChemBioChem 2010, 11, 1521-4.

Translesion synthesis of 1,3-GTG cisplatin DNA lesions


T. Brückl, I. Thoma, A. J. Wagner, P. Knochel, T. Carell

Eur. J. Org. Chem. 2010, 2010, 6517-6519.

Efficient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo-Grignard Method


M. Münzel, D. Globisch, T. Brückl, M. Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell

(Selected as Hot Paper and Highlighted in a Science and Technology Concentrate in Chem. Eng. News 2010, 88 (No 27), 24.)

Angew. Chem. Int. Ed. 2010, 49, 5375-5377.

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain


G. H. Clever, J. Reitmeier, T. Carell, O. Schiemann

(Selected as Hot Paper and Highlighted in a Science and Technology Concentrate in Chem. Eng. News 2010, 88 (No 27), 24.)

Angew. Chem. Int. Ed. 2010, 49, 4927-4929.

Antiferromagnetic Coupling of Stacked CuII-Salen Complexes in DNA


M. Winnacker, V. Welzmiller, R. Strasser, T. Carell

ChemBioChem 2010, 11, 1345-1349.

Development of a DNA Photoaffinity Probe for the Analysis of 8-OxodG-Binding Proteins in a Human Proteome


A. Schlossbauer, S. Warncke, P. E. Gramlich, J. Kecht, A. Manetto, T. Carell, T. Bein

Angew. Chem. Int. Ed. 2010, 49, 4734-4737.

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica


K. Gutsmiedl, D. Fazio, T. Carell

Chemistry 2010, 16, 6877-6883.

High-Density DNA Functionalization by a Combination of Cu-Catalyzed and Cu-Free Click Chemistry


T. Reißner, S. Schneider, S. Schorr, T. Carell

Angew. Chem. Int. Ed. 2010, 49, 3077-3080.

Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase η


A. F. Glas, E. Kaya, S. Schneider, K. Heil, D. Fazio, M. J. Maul, T. Carell

J. Am. Chem. Soc. 2010, 132, 3254-3255.

DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions

2009 – Ludwig-Maximilians-Universität München (Germany)


E. Kaya, K. Gutsmiedl, M. Vrabel, M. Müller, P. Thumbs, T. Carell

ChemBioChem 2009, 10, 2858-2861.

"Synthesis of threefold glycosylated proteins using click chemistry and genetically encoded unnatural amino acids"


B. M. Gaub, C. Kaul, J. L. Zimmermann, T. Carell, H. E. Gaub

Nanotechnolog, 2009, 20, 434002.

"Switching the mechanics of dsDNA by Cu salicylic aldehyde complexation"


A. F. Glas, S. Schneider, M. J. Maul, U. Hennecke, T. Carell

Chemistry 2009, 15, 10387-10396.

"Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions"


A. F. Glas, M. J. Maul, M. Cryle, T. R. M. Barends, S. Schneider, E. Kaya, I. Schlichting, T. Carell

Proc. Natl. Acad. Sci. USA 2009, 106, 11540-11545.

"The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes"


C. Trindler, A. Manetto, J. Eirich, T. Carell

Chem. Commun. (Camb.) 2009, 24, 3583-3584.

"A new ground state single electron donor for excess electron transfer studies in DNA"


K. Gutsmiedl, C. T. Wirges, V. Ehmke, T. Carell

Org. Lett. 2009, 11, 2405-2408.

"Copper-Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition"


M. Müller, T. Carell

Curr. Opin. Struct. Biol. 2009, 19, 277-285.

"Structural biology of DNA photolyases and cryptochromes"


S. Warncke, A. Gégout, T. Carell

ChemBioChem 2009, 10, 728-734.

"Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases"


S. Shachar, O. Ziv, S. Avkin, S. Adar, J. Wittschieben, T. Reißner, S. Chaney, E. C. Friedberg, Z. Wang, T. Carell, N. Geacintov, Z. Livneh

EMBO J. 2009, 28, 383-393.

"Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals"


S. Schneider, S. Schorr, T. Carell

Curr. Opin. Struct. Biol. 2009, 19, 87-95.

"Crystal structure analysis of DNA lesion repair and tolerance mechanisms"


M. Winnacker, S. Breeger, R. Strasser, T. Carell

ChemBioChem 2009, 10, 109-118.

"Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions"


MT. Brückl, D. Globisch, M. Wagner, M. Müller, T. Carell (Selected as Hot Paper and Highlighted in a Science and Technology Concentrate in Chem. Eng. News, 2009, 87 (No 38), 35.)

Angew. Chem. Int. Ed. 2009, 48, 7932-7934.

"Parallel Isotope-Based Quantification of Modified tRNA Nucleosides"


T. Reißner, S. Schorr, T. Carell

Angew. Chem. Int. Ed. (Highlight), 2009, 48, 7293-7295.

"Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair"


C. T. Wirges, J. Timper, M. Fischler, A. S. Sologubenko, J. Mayer, U. Simon, T. Carell

Angew. Chem. Int. Ed. (Highlight), 2009, 48, 219-223.

"Controlled Nucleation of DNA Metallization"

2008 – Ludwig-Maximilians-Universität München (Germany)


R. Pokorny, T. Klar, U. Hennecke, T. Carell, A. Batschauer, L. O. Essen

Proc. Natl. Acad. Sci. USA 2008, 105,21023-21027.

Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome


E. Bürckstümmer, T. Carell

Chem. Commun. (Camb). 2008, 34,4037-4039.

Synthesis and properties of DNA containing a spore photoproduct analog


F. Coste, M. Ober, Y.-V. Le Bihan, M. A. Izquierdo, N. Hervouet, H. Mueller, T. Carell, B. Castaing

Chem. Biol. 2008, 15,706-717.

Bacterial Base Excision Repair Enzyme Fpg Recognizes Bulky N7-Substituted-FapydG Lesion via Unproductive Binding Mode


H. Müller, M. Hopfinger, T. Carell

ChemBioChem 2008, 9,1617-1622.

Synthesis of a Stabilized Version of the Imidazolone DNA Lesion


P. M. E. Gramlich, C. T. Wirges, J. Gierlich, T. Carell

Org. Lett. 2008, 10,249-251.

Synthesis of Modified DNA by PCR with Alkyne-Bearing Purines Followed by a Click Reaction


M. Fischler, A. Sologubenko, J. Mayer, G. Clever, G. A. Burley, J. Gierlich, T. Carell, U. Simon

Chem. Commun. (Camb.) 2008, 169-171.

Chain-like assembly of gold nanoparticles on artificial DNA templates via "click chemistry"


M. J. Maul, T. R. M. Barends, A. F. Glas, M. J. Cryle, T. Domratcheva, S. Schneider, I. Schlichting, T. Carell

Angew. Chem. Int. Ed. 2008, 47,10076-10080.

Crystal Structure and Mechanism of a DNA (6-4) Photolyase


P. M. E. Gramlich, C. T. Wirges, A. Manetto, T. Carell

Angew. Chem. Int. Ed. 2008, 47,8350-8358.

Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction


P. M. E. Gramlich, S. Warncke, J. Gierlich, T. Carell

Angew. Chem. Int. Ed. 2008, 47,3442-3444.

Click-Click-Click: Single to Triple Modification of DNA


D. Kuch, L. Schermelleh, S. Manetto, H. Leonhardt, T. Carell

Angew. Chem. Int. Ed. 2008, 47,1515-1518.

Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1


S. Bareyt, T. Carell

Angew. Chem. Int. Ed. 2008, 47,181-184.

Selective Detection of 5-Methylcytosine Sites in DNA


F. Büsch, J. C. Pieck, M. Ober, J. Gierlich, G. W. Hsu, L. S. Beese, T. Carell

Chemistry 2008, 14,2125-2132.

Dissecting the Differences between the αand β Anomers of the Oxidative DNA Lesion FaPydG

2007 – Ludwig-Maximilians-Universität München (Germany)


T. Brückl, F. Klepper, K. Gutsmiedl, T. Carell

Org. Biomol. Chem. 2007, 5,3821-3825.

A short and efficient synthesis of the tRNA nucleosides PreQ0 and archaeosine


G. E. Damsma, A. Alt, F. Brueckner, T. Carell, P. Cramer

Nat. Struct. Mol. Biol. 2007, 14,1127-1133.

Mechanism of transcriptional stalling at cisplatin-damaged DNA


A. Alt, K. Lammens, C. Chiocchini, A. Lammens, J. C. Pieck, D. Kuch, K.-P. Hopfner, T. Carell

Science 2007, 318, 967-970.

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase η


D. I. Rozkiewicz, J. Gierlich, G. A. Burley, K. Gutsmiedl, T. Carell, B. J. Ravoo, D. N. Reinhoudt

ChemBioChem 2007, 8,1997-2002.

Transfer Printing of DNA by "Click" Chemistry


M. Fischler, U. Simon, H. Nir, Y. Eichen, G. A. Burley, J. Gierlich, P. M. E. Gramlich, T. Carell

Small 2007, 3, 1049-1055.

Formation of Bimetallic Ag-Au Nanowires by Metallization of Artificial DNA Duplexes


A. Manetto, D. Georganakis, L. Leondiadis, T. Gimisis, P. Mayer, T. Carell, C. Chatgilialoglu

J. Org. Chem. 2007, 72, 3659-3666.

Independent Generation of C5′-Nucleosidyl Radicals in Thymidine and 2′-Deoxyguanosine


C. T. Wirges, P. M. E. Gramlich, K. Gutsmiedl, J. Gierlich, G. A. Burley, T. Carell

QSAR Comb. Sci. 2007, 26, 1159-1164.

Pronounced Effect of DNA Hybridization on Click Reaction Efficiency


F. Spada, A. Haemmer, D. Kuch, U. Rothbauer, L. Schermelleh, E. Kremmer, T. Carell, G. Längst, H. Leonhardt

J. Cell Biol. 2007, 176, 565

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells


F. Brueckner, U. Hennecke, T. Carell, P. Cramer

Science 2007, 315, 859-862.

CPD Damage Recognition by Transcribing RNA Polymerase II


H. Müller, T. Carell

Eur. J. Org. Chem. 2007, 9, 1438-1445.

A Carbocyclic Analog of the Oxidatively Generated DNA Lesion Spiroiminodihydantoin


W. J. Schreier, T. E. Schrader, F. O. Koller, P. Gilch, C. E. Crespo-Hernández, V. N. Swaminathan, T. Carell, W. Zinth, B. Kohler

Science 2007, 315, 625-629.

Thymine Dimerization in DNA is an Ultrafast Photoreaction


G. H. Clever, C. Kaul, T. Carell

Angew. Chem. Int. Ed. 2007, 46, 6226-6236.

DNA-metal base pairs


D. M. Hammond, A. Manetto, J. Gierlich, V. A. Azov, P. M. E. Gramlich, G. A. Burley, M. Maul, T. Carell

Angew. Chem. Int. Ed. 2007, 46, 4184-4187.

DNA Photography: An Ultrasensitive DNA-Detection Method Based on Photographic Techniques


U. Hennecke, D. Kuch, T. Carell

Synthesis, 2007, 6, 929-935.

A General Route to 4-C-Substituted Pyrimidine Nucleosides


F. Klepper, E.-M. Jahn, V. Hickmann, T. Carell

Angew. Chem. Int. Ed. 2007, 46, 2325-2327.

Synthesis of the Transfer-RNA Nucleoside Queuosine by Using a Chiral Allyl Azide Intermediate


G. H. Clever, T. Carell

Angew. Chem. Int. Ed. 2007, 46, 250-253.

Controlled Stacking of 10 Transition-Metal Ions inside a DNA Duplex


J. Gierlich, K. Gutsmiedl, P. M. E. Gramlich, A. Schmidt, G. A. Burley, T. Carell

Chemistry 2007, 13, 9486-9494.

Synthesis of Highly Modified DNA by a Combination of PCR with Alkyne-Bearing Triphosphates and Click Chemistry


C. Chatgilialoglu, M. Guerra, P. Kaloudis, C. Houée-Lévin, J. L. Marignier, V. N. Swaminathan, T. Carell

Chemistry 2007, 13, 8979-8984.

Ring Opening of the Cyclobutane in a Thymine Dimer Radical Anion

2006 – Ludwig-Maximilians-Universität München (Germany)


K. Tanaka, G. H. Clever, Y. Takezawa, Y. Yamada, C. Kaul, M. Shionoya, T. Carell

Nature Nanotechnol. 2006, 1, 190-194.

Programmable self-assembly of metal ions inside artificial DNA duplexes


G. H. Clever, Y. Soltl, H. Burks, W. Spahl, T. Carell

Chemistry 2006, 12, 8708.

Metal-Salen-Base-Pair Complexes Inside DNA: Complexation Overrides Sequence Information


J. C. Pieck, U. Hennecke, A. J. Pierik, M. G. Friedel, T. Carell

J. Biol. Chem. 2006, 281, 36317.

Characterization of a New Thermophilic Spore Photoproduct Lyase from Geobacillus stearothermophilus (SplG) with Defined Lesion Containing DNA Substrates


T. Klar, G. Kaiser, U. Hennecke, T. Carell, A. Batschauer, L. O. Essen

ChemBioChem 2006, 7, 1798.

Natural and Non-natural Antenna Chromophores in the DNA Photolyase from Thermus Thermophilus


S. Breeger, M. von Meltzer, U. Hennecke, T. Carell

Chemistry 2006, 12, 6469-6477.

Investigation of the pathways of excess electron transfer in DNA with flavin-donor and oxetane-acceptor modified DNA hairpins


J. Gierlich, G. A. Burley, P. M. E. Gramlich, D. M. Hammond, T. Carell

Org. Lett. 2006, 8, 3639-3642.

Click Chemistry as a Reliable Method for the High-Density Postsynthetic Functionalization of Alkyne-Modified DNA


M. G. Friedel, J. C. Pieck, J. Klages, C. Dauth, H. Kessler, T. Carell

Chemistry 2006, 12, 6081-6094.

Synthesis and Stereochemical Assignment of DNA Spore Photoproduct Analogues


J. C. Pieck, D. Kuch, F. Grolle, U. Linne, C. Haas, T. Carell

J. Am. Chem. Soc. 2006, 128, 1404-1405.

PNA-Based Reagents for the Direct and Site-Specific Synthesis of Thymine Dimer Lesions in Genomic DNA


G. A. Burley, J. Gierlich, M. R. Mofid, H. Nir, S. Tal, Y. Eichen, T. Carell

J. Am. Chem. Soc. 2006, 128, 1398-1399.

Directed DNA Metallization


M. G. Friedel, O. Berteau, J. C. Pieck, M. Atta, S. Ollagnier-de-Choudens, M. Fontecave. T. Carell

Chem. Commun. (Camb.) 2006, 445-447.

The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion

2005 – Ludwig-Maximilians-Universität München (Germany)


M. Ober, H. Müller, C. Pieck, J. Gierlich, T. Carell

J. Am. Chem. Soc. 2005, 127, 18143-18149.

Base Pairing and Replicative Processing of the Formamidopyrimidine-dG DNA Lesion


A. Manetto, S. Breeger, C. Chatgilialoglu, T. Carell

Angew. Chem. Int. Ed. 2005, 45, 318-321.

Complex Sequence Dependence by Excess-Electron Transfer through DNA with Different Strength Electron Acceptors


G. H. Clever, K. Polborn, T. Carell

Angew. Chem. Int. Ed. 2005, 44, 7204-7208.

A Highly DNA-Duplex-Stabilizing Metal-Salen Base Pair


F. Klepper, K. Polborn, T. Carell

Helv. Chim. Acta 2005, 88, 2610-2616.

Robust synthesis and crystal-structure analysis of 7-cyano-7-deazaguanine (PreQ0 base) and 7-(aminomethyl)-7-deazaguanine (PreQ1 base)


M. G. Friedel, M. K. Cichon, T. Carell

Org. Biomol. Chem. 2005, 3, 1937-1941.

Model compounds for (6-4) photolyases: a comparative flavin induced cleavage study of oxetanes and thietanes


M. v. Meltzer, M. Marsch, T. Carell, K. Harms

Acta. Cryst. E. 2005, 3, 1937-1941.

(1S,2R,4R,5R)-tert-Butyl N-(4-hydroxymethyl-6-oxabicyclo[3.1.0]hex-2-yl)carbamate

2004 – Ludwig-Maximilians-Universität München (Germany)


A. Mees, T. Klar, P. Gnau, U. Hennecke, A. P. M. Eker, T. Carell and L.-O. Essen

Science 2004, 306, 1789-1793.

Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion After in Situ Repair


L. M. Kundu, U. Linne, M. Marahiel, T. Carell

Chemistry 2004, 10, 5697-5705.

RNA Is More UV Resistant than DNA: The Formation of UV-Induced DNA Lesions is Strongly Sequence and Conformation Dependent


G. W. Hsu, M. Ober, T. Carell, L. S. Beese

Nature 2004, 431, 217-221.

Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase


F. Coste, M. Ober, T. Carell, S. Boiteux, C. Zelwer, and B. Castaing

J. Biol. Chem. 2004, 279, 44074-44083.

Structural Basis for the Recognition of the FapydG Lesion (2,6-Diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA Glycosylase


M. v. Meltzer, M. Marsch, T. Carell and K. Harms

Acta. Cryst. E. 2004, E60, 2515-2516.

(1S,2R,4S,5R)-tert-Butyl 7-oxo-3-oxa-6-azatricyclo[,4]octane-6-carboxylate


B. Giese, B. Carl, T Carl, T. Carell, C. Behrens, U. Hennecke, O. Schiemann, E. Feresin

Angew. Chem. Int. Ed. 2004, 43, 1848-1851.

Excess electron transport through DNA: A single electron repairs more than one UV-induced lesion


C. Behrens, M. Cichon, F. Grolle, U. Hennecke, T. Carell

Top. Curr. Chem. 2004, 236, 187-204.

Excess electron transfer in defined donor-nucleobase and donor-DNA-acceptor systems


M. Ober, M.Marsch, K. Harms, T. Carell

Act. Cryst. E. 2004, E60, o1191-o1192.

A carbocyclic analogue of a protected a-D-2-deoxyribosylamine


C. Haas, K. Kräling, M. Cichon, N. Rahe and T. Carell

Angew. Chem. Int. Ed. 2004, 43, 1842-1844.

Excess electron transfer driven DNA repair does not depend on the transfer direction


S. Breeger, U. Hennecke and T. Carell

J. Am. Chem. Soc. 2004, 126, 1302-1303.

Excess Electron Transfer Based Repair of a cis-syn Thymine Dimer in DNA is only Weakly Sequence Dependent

Philipps-Universität Marburg (Germany)


M. Ober, U. Linne, J. Gierlich, T. Carell

Angew. Chem. Int. Ed. 2003, 42, 4947-4951.

The two main oxydative DNA lesions 8-oxo-7,8-dihydroguanine and 2,6-diamino-5-formamido-4-hydroxypyrimidine exhibit strongly different pairing characteristics


N. Rahe, C. Rinn, T. Carell

Chem. Commun. (Camb.) 2003, 2120-2121.

Development of Donor/Acceptor Modified DNA Hairpins for the Investigation of Charge Hopping Kinetics in DNA


A. Mees, C. Behrens, A. Schwögler, M. Ober, T. Carell

Eur. J. Org. Chem. 2003, 2670-2677.

Redoxactive Oligonucleotides: Synthesis and Properties of Flavocoenzyme-DNA


C. Behrens, T. Carell

Chem. Commun. (Camb.) 2003, 1632-1633.

Excess Electron Transfer in Flavin-Capped, Thymine Dimer-Containing DNA Hairpins


T. Carell, C. Behrens, J. Gierlich

Org. Biomol. Chem. 2003, 1, 2221-2228.

Electron transfer Through DNA and Metal-Containing DNA


M. Cichon, C. Haas, F. Grolle, A. Mees, T. Carell

J. Am. Chem. Soc. 2002, 124 13984-13985.

Efficient Interstrand Excess Electron Transfer in PNA:DNA Hybrids


L. Kundu, L. Burgdorf, T. Carell

ChemBioChem 2002, 3, 1053-1060.

Thymine Dimer Containing Molecular Beacons for the Investigation of Photolyase Activity in Cell Extracts


C. Behrens, M.Ober, T. Carell

Eur. J. Org. Chem. 2002, 3, 3281-3289.

Flavin-Capped DNA Hairpins for Excess Electron Transfer Studies in DNA


C. Behrens, L. Burgdorf, A. Schwögler, T. Carell

Angew. Chem. Int. Ed. 2002, 41, 1763-1766.

Shallow distance dependence of excess electron transfer through DNA


M. Cichon, S. Arnold, T. Carell

Angew. Chem. Int. Ed. 2002, 41, 767-770.

Repair of the oxetane lesion by (6-4) DNA photolyases requires a reduced and deprotonated flavin


L. Burgdorf, T. Carell

Chemistry 2002, 8, 293-301.

Synthesis, stability, and conformation of the Formamidopyrimidine G DNA lesion


T. Carell, L. Burgdorf, L. Kundu

Curr. Opin. Chem. Biol. 2001, 5, 491-498.

The Mechanism of Action of Photolyase


D. Nikova, B. de Frooth, K. Groener, C. Wyman, A. Eker, T. Carell, J. Greve

Biophys. J. 2000, 78, 1552.

Specific and non-specific interactions in DNA repair processes


A. Schwögler, L. Burgdorf, T. Carell

Angew. Chem. Int. Ed. 2000, 39, 3918-3920.

Self-Repairing DNA Based on a Reductive Electron Transfer Through the Base Stack


A. Schwögler, T. Carell

Helv. Chim. Acta. 2000, 83, 2452-2463.

Synthesis and Properties of Flavin Nucleosides


A. Schwögler, T. Carell

Org. Lett. 2000, 2, 1415-1418.

Towards Catalytically Active Oligonucleotides: Synthesis and Properties of a Flavin Nucleotide and its Incorporation in DNA


J. Butenandt, R. Epple, E.-U. Wallenborn, A. Eker, V. Gramlich, T. Carell

Chemistry 2000, 6, 62-72.

DNA-Photolyase Models: A Comparative Cleavage Study With Cyclobutane Uracil- and Thyminedimer Model Compounds

ETH-Zürich (Switzerland)


O. Kleiner, J. Butenandt, T. Carell, A. Batschauer

Eur. J. Biochem. 1999, 264, 161-167.

Class II DNA photolyase from Arabidopsis thaliana contains FAD as cofactor


J. Butenandt, R. Epple, E.-U. Wallenborn, A. Eker, V. Gramlich, T. Carell

Chemistry 2000, 6, 62-72.

DNA-Photolyase Models: A Comparative Cleavage Study With Cyclobutane Uracil- and Thyminedimer Model Compounds


R. Epple, T. Carell

J. Am. Chem. Soc. 1999, 121, 7318-7329.

Efficient Light Dependent DNA-Repair Requires a Large Cofactor Separation


J. Butenandt, L. Burgdorf, T. Carell

Angew. Chem. Int. Ed. 1999, 38, 708-711.

"Base Flipping": Photodamaged DNA-RNA Duplexes Are Poor Substrates for Photoreactivating DNA-Repair Enzymes


T. Carell, H. Schmid, M. Reinhard

J. Org. Chem. 1998, 63, 8741-8747.

A Convenient Synthesis of a Flavin- and a Deazaflavin-Amino Acid and their Incorporation into Oligopeptides


T. Carell, R. Epple

Eur. J. Org. Chem. 1998, 7, 1245-1248.

Repair of UV-light Induced DNA Lesions: A Comparative Study with Model Compounds


R. Epple, T. Carell

Angew. Chem. Int. Ed. 1998, 37, 938-941.

Flavin and Deazaflavin Containing Model Compounds Mimic the Energy-Transfer Step in Type II DNA-Photolyases


J. Butenandt, A. P. M. Eker, T. Carell

Chemistry 1998, 4, 642-654.

Synthesis, Crystal-Structure and Enzymatic Evaluation of a DNA-Photolesion Isostere


T. Carell, R. Epple, V. Gramlich

Helv. Chim. Acta 1997, 80, 2191-2203.

Synthesis and Structure of (Carboxymethyl)-Functionalized Cyclobuta-Fused Uracil Dimers


R. Epple, E.-U. Wallenborn, T. Carell

J. Am. Chem. Soc. 1997, 119, 7440-7451.

Investigation of Flavin-Containing DNA-Repair Model Compounds


T. Carell, J. Butenandt

Angew. Chem. Int. Ed. 1997, 36, 1461-1464.

Towards Artificial DNA-Repair Enzymes: Incorporation of a Flavin Amino Acid into DNA-Binding Oligopeptides


T. Carell, R. Epple, V. Gramlich

Angew. Chem. Int. Ed. 1996, 35, 620-623.

Synthesis of Flavin‐Containing Model Compounds for DNA Photolyase Mediated DNA Repair


T. Carell

Chimia 1995, 49, 365-373.

Sunlight-Induced DNA Lesions. Lesion Structure, Mutation Characteristics and Repair

MIT (Cambridge, USA)


A. S. Fang, P. Vouros, C. C. Stacey, G. H. Kruppa, F. H. Laukien, E. A. Wintner, T. Carell, J. Rebek

Comb. Chem. & High Throughput Screening 1998, 23-33.

Rapid characterization of combinatorial libraries using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry


E. A. Wintner, J. Shipps, T. Carell, J. Rebek, Y. Dunayevskiy, P. Vouros

Proc. Natl. Acad. Sci. USA 1996, 93, 6152-6157.

Application of Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry in the Determination of Molecular Diversity


T. Carell, E. A. Wintner, J. Rebek, Jr., Y. Dunayevskiy, P. Vouros

Anal. Chem. 1995, 67, 2906-2915.

Characterization of the Complexity of Small-Molecule Libraries by Electrospray Ionization Mass Spectrometry


T. Carell, E. A. Wintner, J. Rebek, Jr.

Angew. Chem. Int. Ed. 1994, 33, 2061-2064.

A Solution-Phase Screening Procedure for the Isolation of Active Compounds from a Library of Molecules


T. Carell, E. A. Wintner, A. Bashir-Hashemi, J. Rebek, Jr.

Angew. Chem. Int. Ed. 1994, 33, 2059-2061.

A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules

Max-Planck-Institut for Medical Research (Heidelberg, Germany)


T. Carell, E. A. Wintner, A. Bashir-Hashemi, J. Rebek, Jr.

Angew. Chem. Int. Ed. 1994, 33, 2059-2061.

A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules


H. A. Staab, T. Carell

Angew. Chem. Int. Ed. 1994, 33, 1466-1468.

Synthesis and Properties of a Vertically Stacked Porphyrin1-Porphyrin2-Quinone Cyclophane


H. A. Staab, T. Carell, A. Döhling

Chem. Ber. 1994, 127, 223-229.

Syntheses and Properties of New Quinone-Bridged Diphenyl- and Tetraphenylporphyrins


C. Krieger, M. Dernbach, G. Voit, T. Carell, H. A. Staab

Chem. Ber. 1993, 126, 811-821.

Conformational Mobility and Crystal Structures of Porphyrin-Quinone Cyclophanes

Other publications and activity



C. Thilgen, H. Wennemers, T. Carell

Angew. Chem. Int. Ed. 2021, 10.1002/anie.202101232

François Diederich (1952-2020): 40 Years of Organic Chemistry



A. G. Beck-Sickinger, T. Carell, S. Dehnen, W. Leitner, P. R. Schreiner, H. Wennemers

Angew. Chem. Int. Ed. 2020, doi:10.1002/anie.202008469

From Scientists to Scientists—Moving Angewandte into the Future


T. Carell

Angew. Chem. Int. Ed. 2015, doi:10.1002/anie.201509770

DNA Repair.


E. Parsa, A. Schröder, T. Carell

Naturwissenschaftliche Rundschau 2015, 3, 128-133.

Modifizierte DNA-Basen erweitern das Verständnis der Genregulation


Organisation des 8. Nachwuchswissenschaftler Symposiums "Bioorganische Chemie", Heidelberg 20.-22. September 1999


T. Carell

Nature (News & Views). 2011, 469, 45-46.

Molecular computing: DNA as a logic operator


J. Cadet, T. Carell, L. Cellai, C. Chatgilialoglu, T. Gimisis, M. Miranda, P. O'Neill, J.-L. Ravanat, M. Robert

Chimia, 2008, 62, 742-749.

DNA damage and radical reactions: mechanistic aspects, formation in cells and repair studies


T. Carell, P. Cramer, K.-H. Hopfner

Nucleic Acids Symp. Ser. 2008, 15, 103.

The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution


M. Friedel, M. K. Cichon, T. Carell

CRC Handbook of Photochemistry and Photobiology 2004, 141/1-141/22.

DNA Repair: Photochemistry


T. Carell

Nature 2004, 431, 398.

German reform would make little difference


P. H. Seeberger, T. Carell

Curr. Opin. Chem. Biol. 2003, 7, 715-716.



Org. Biomol. Chem. 2003, 1, XI.

Profile Thomas Carell


T. Carell

Chemie Heute. 2000 ⁄ 2001, 102-105.

Damit unser Erbgut intakt bleibt


Verschiedene Beiträge zur Darstellung der Jungen Akademie


Organisation des 8. Nachwuchswissenschaftler Symposiums "Bioorganische Chemie", Heidelberg 20.-22. September 1999


Chimia, 1997, 12, 952-962.

Conference report about the 36. IUPAC Congress: Frontiers in Chemistry, New Perspectives for the 2000s


Angew. Chem. 1996, 108, 990-991try, Book Report: G. Quinkert, E. Egert, C. Griesinger

Aspekte der Organischen Chemie, Struktur, Verlag Helv. Chim. Acta, Basel 1995

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