CARELL GROUP News – Epigenetics

New pathway for cytosine demethylation discovered


Chemical modification of DNA subunits contribute to the regulation of gene expression. The Carell group has now deciphered a new pathway can reactivate genes that have been silenced in this way, while avoiding the risk of damaging the DNA.

Read more in our press release / Pressemitteilung.

Or proceed directly to our publication:

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

K. Iwan, R. Rahimoff, A. Kirchner, F. Spada, A.S. Schröder, O. Kosmatchev, S. Ferizaj, J. Steinbacher, E. Parsa, M. Müller & T. Carell
Nat. Chem. Biol. 2017 doi:10.1038/nchembio.2531

 

Zum Anfang