CARELL GROUP – Organic and Biomolecular Chemistry

DNA Materials – Repair of DNA Damage – RNA Modifications

An introduction to the CARELL GROUP

carell group laboratories



The high-tech campus Großhadern, where the LMU Departments of Pharmacy, Chemistry and Biochemistry have been located since 1999, is the home base of the Carell group.

With a foundation in synthetic organic chemistry, the group reaches out to unravel the mysteries of the molecules of life, with emphasis on the nucleic acids. These versatile molecules are both extremely stable and extremely diverse in their chemistry.

In the case of DNA, highly efficient replication and repair systems have ensured the stability of the genetic code for millions of years. In the case of RNA, about 170 different building blocks of RNA have been identified so far. The function of these molecules spans from information storage and inheritance to the regulation of life-processes and fascinating catalytic properties. It is at this interface between Chemistry and Biology where the Carell group positions itself.


More fossils of the early Earth
Martin Rossa, 13/03/2018
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We present simple cascade reactions that lead to the formation of methylated and aminoacylated nucleosides under prebiotic conditions.

Now Published!
Markus Müller, 08.03.2018
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A type-set version of "Non-canonical bases in the genome: The regulatory information layer in DNA" is now online in Angewandte Chemie.

Many thanks to the OC3 students!
Thomas Carell, 27.02.2018
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Modified Nucleosides can be considered as molecular fossils
Martin Rossa, 11.01.2018
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Modified and canonical nucleosides are accessible in parallel through continous wet-dry cycles. Nat. Commun.

New Reagent for Quantitative Proteomics
Martin Rossa, 10.01.2018
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We present a new isobaric labelling reagent for quantitative mass spectrometry that allows more precise quantification in complex samples. Angew. Chem. Int. Ed.

New demethylation pathway discovered
Markus Müller, 30.11.2017
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Fluorinated cytosine analogs reveal direct C-C bond cleavage in vivo. Nat. Chem. Biol.


Focus of the group



A Synonym for Successful DNA Research


Our research is centered around the Chemical Biology of Nucleic Acids. We have a special interest in RNA and DNA modifications, including regulatory/epigenetic modifications as well as detrimental DNA lesions and their repair. An additional research focus includes synthetic modifications, such as applying click chemistry to DNA, building brighter probes for diagnostics and optimizing gene transfer.



Novel Phosphoramidites of New Epigenetic Bases


The Carell group has developed sophisticated tools for DNA and RNA research. These are isotopically labelled nucleosides for tracing and quantification. Our phosphoramidites are now sold through GlenResearch. Find out what is available.


Publications CARELL GROUP

The Complete List


Here you will find a complete list of our published research in high-impact journals like Science, Nature, Cell and Angewandte Chemie.

Links will guide you to the publishers' websites. Latest papers on top.


Lectures and Courses



Prof. Carell teaches bioorganic chemistry (OC3) in the Bachelor of Chemistry and Biochemistry program. Together with Dr. Müller, he offers a program in Chemical Biology, consisting of two lectures and a practical course. In the Supplements section, students can find study examples for their exam preparation.

The way to our laboratories

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